Peak plasma concentration: 58.9 ng/mL (healthy subjects); 63.1 ng/mL (patients with . At one point, I had about 3 weeks of relief after taking Ivermectin every other day for about 4 doses, but it did come back again. They are the ones re-infecting everyone else. In terms of morbidity, at 1.5 million disability-adjusted life years, scabies ranks higher than several other important NTDs, including dengue (0.83 million), onchocerciasis (0.43 million), and trypanosomiasis (0.56 million) [5]. When higher concentrations (1 mg/kg) of a long-acting formulation were used, 100% efficacy was achieved in a single dose [41]. It is a fair amount of work keeping the site up. Yes Dermatology Department, Henri Mondor Hospital, AP-HP, UPEC, Crteil, France, Affiliations high heat dry. The recent development of a porcine model for human scabies [51] holds significant potential as a tool for scabies drug development, as pigs develop similar clinical responses to S. scabiei infestation and have similar skin physiology. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Vacuum. Thank you, I just took my moxi and I learned from it on here. Please ask any questions, I will try to help as much as possible, Please hang in there and remember things can and will get better! Approximately around two weeks ago, after weeks of persistent itching and long research I confirmed I had scabies despite the doctors dismissing it as eczema. Prospects for Moxidectin as a New Oral Treatment for Human Scabies. Multiple drugs can be used for treatment, but resistance to conventional therapy is increasing throughout the years. I also sprayed and wiped down every morning. A colored scanning electron micrograph of a scabies mite. Press the plunger to squirt the gel out into an animals mouth (or onto a spoon). The primary objectives of this review were to synthesise the diverse literature published on . Take a photograph w/ your phone camera. Differences in observed clinical efficacy may relate to the severity of infestation or pharmacokinetic differences between different species. Result: Old bites healing. Take the dose for your weight. Even the doctor was pretty at ease with sitting in the room and talking with me, or at least it seemed as if he was. So you shouldn't take another dose until the 16 weeks is up. Although millions of doses have been administered for onchocerciasis, with few well-documented serious adverse effects outside Loa loa-endemic areas, there remain concerns regarding its safety in children weighing less than 15 kg and in pregnancy and breastfeeding, although no increased risk has been found in cases of inadvertent exposure in these groups [20,21]. (Permethrin is an insecticide used in insect-repellent clothing and in some mosquito nets.). A human caretaker of the pig had recently been diagnosed with a Sarcoptes spp. I believe I replaced this once a week or so, but only a dollar so not too bad. None of us had a rash--the burrows and bites can be hidden for half a year if left untreated. I came across the Maximpulse website and decided to order Moxidectin and took some last night. Montelucast (Singulair) stops your immune cells from releasing HISTAMINE. A subreddit related to scabies and treatments, Press J to jump to the feed. 5f.OliveOil & MineralOil: Effective. Notably, topical 0.5% ivermectin has been approved in the US for the treatment of head lice in infants over 6 months of age, although bioavailability is much lower than that of oral administration [23]. Infectious Diseases & Immunology Division, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, . A qualitative study revealed barriers to appropriate use in scabies-endemic communities in northern Australia, including a lack of privacy to undertake whole-body application, insufficient facilities to rinse the cream off, and discomfort using the cream in tropical environments [13]. Transient depression, ataxia and recumbency may be seen when very young or debilitated animals are treated. You can get immune or your skin gets thicker because of scratching and your skin doesnt absorb the premetherin as effectively. Privacy Policy. For instance, for a 125 pound dose, set the ring at the 250 mark. I would spray and wipe this down every morning with Lysol or some type of disinfectant spray because believe me Lysol gets very expensive after a little while. respect of any healthcare matters. A syringe of 2% moxidectin contains enough to treat an 1150 pound horse. It was about 2 weeks before Christmas. I weigh around 160 so I took 1.6ml but I wanted to know should I take more? Ivermectin, which was discovered in Streptomyces avermitilis bacteria in 1975, is a powerful drug that kills many types of parasitic worms. Skin scrapings for sarcoptic mange mites should be deep enough to examine the full thickness of the epidermis and produce a sample that is tinged with blood. Approximately around two weeks ago, after weeks of persistent itching and long research I confirmed I had scabies despite the doctors dismissing it as eczema. I got scabies in November 2020, presumably from a 6 day hotel stay. Dosed the two of us 23 days ago. Adverse events will be summarized by MedDRA preferred term. Reddit and its partners use cookies and similar technologies to provide you with a better experience. No, Is the Subject Area "Mites" applicable to this article? Finally, more data on the safety of moxidectin in young children and in pregnancy, and breastfeeding must be accumulated if this drug is to proceed as a genuine new candidate for the sustainable control of scabies. Pinch the skin together at the area of interest and scrape the skin firmly to . Moxidectin is very promising, given its proven clinical efficacy against mange in animals, existing safety data in humans, and pharmacokinetic properties that may make it suitable for a single-dose regimen. Concentrations of moxidectin in plasma will be assessed by collection of plasma samples at pre-specified intervals after dosing with oral moxidectin. And I grabbed my bike and went out for a ride, with scratch scars on my arms and legs, but I was cured. This Pill Can End It. To recap, I took a single dose (based on my body weight) on May 1. This paper will review the mechanisms of resistance proposed in the literature and some of the . It seems I could get it about 95% gone but it would come back. Registered number: 10004395 Registered office: Fulford Grange, Micklefield Lane, Rawdon, Leeds, LS19 6BA. Looking at the prospects for scabies drug development, the target product profile for any new drug must be considered carefully. While frequently associated with poverty and overcrowding, scabies epidemics also remain problematic in developed countries. We have left our house, but that doesn't matter bc if they are under one person's skin, it will start all over again! It was all over my arms, but not really on the hands. I search for good deals on good products for myself and tell you where to find them. Some studies show excellent efficacy as a single 0.2 mg/kg dose, with 100% cure at day 14 in cattle, In a clinical study humans were given doses of moxidectin from 3 mg to 36 mg. disposable syringes with blunt tips can be very cheap. When used to treat scabies, it is called an off label treatment. You can even mix it with a little applesauce or strawberry jam to make it more palatable. As the saying goes IGNORANCE IS DEFINITELY BLISS! Notably, the dose selection of 200 g/kg is largely based on its potent activity against nematodes at this concentration, and no formal dose-finding studies have been undertaken for scabies, with some studies reporting reduced efficacy (<70%) at concentrations below 200 g/kg [3436], suggesting this dose may be around the minimum threshold of mite toxicity. Three cohorts of six subjects per cohort are planned. Result: No mites jumping on my face at night. Clinically relevant laboratory abnormalities at Screening, including: To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Each subject will receive the same number of tablets made up of moxidectin 2 mg tablets and placebo tablets to maintain the blind. The weird thing about my lower legs like from the knee down, it that around each hair follicle it seem to have a red circle. And buy like two of three of these for the day. Significantly less bites. Scan this QR code to download the app now. HE is still infected! Moxidectin binding increases target GluCl permeability, resulting in influx of chloride ions and dysfunction of the excretory pore, flaccid paralysis, and death of the parasite through . Scabies Means Misery. MDGH Job Listings Feb 2020. Lots of testing with mice, rats, sheep, cattle, dogs, pigs and horses. This will lead to adverse effects (AEs)or what you and I call side effects. When I to the Moxi I threw it up (gross) but I took it again and Im truly believing this will finally cure me, I thought I had read somewhere that taking NAC reduces moxi in your system. But if you have taken moxidectin, DO NOT take ivermectin for about three months. I stopped taking NAC for this reason. I have Scabies and I have taken Ivermectin First Dose, and Second Dose its now 2 weeks after I have taken the pills. Knowing what I know now I can not really blame them. When folks use the product links I can see they care. All over your body, that you combine applying Permethrin "5%" with the oral Vermectin dose on the same day. Scabies is an infestation of the skin by the mite Sarcoptes scabiei. Be aware moxidectin and ivermectin have been approved by the FDA in humans but only for treating a disease called river blindness. Cookie Notice Trying out Moxidectin. Exfoliate with green 3m scrubbers. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. So it appears, with a real minimum of information, that a human effective dose would be between 0.15 and 0.6 mg per kg or approximately 0.1 to 0.3 mg per pound. Clinical features Scabies is highly contagious and there may be a history of contact with other dogs, [] When I went they asked what I was there for, I told them a rash and that I thought I might be scabies. Each gram or ml of paste is a dose for 101 lbs, so its approximately 0.1 ml per 10 pounds of body weight. In the third group, everyone in the village who agreed to participate got one ivermectin pill; those with confirmed scabies got a second pill a week later. 2 MDGH-MOX-2001 Flipchart, version 2.0 25/06/2020 When a person first gets scabies, he or she has an itchy rash in a few places on the body I use it topically rather than orally, Your skin absorbs 63% of lotion andor medicine you put on it . It is well documented that certain species of arthropods have reduced sensitivity to moxidectin compared to ivermectin. Burrowing skin mites drive victims mad with itching, but distribution of a few pills can drive the infestation from entire communities. We don't know when and how it started, but it is HELL! Where two doses were given, follow-up was frequent, and community visitors were continuously screened and treated, ivermectin MDA was more successful [18]. Ivermectin is available at relatively low cost or has been provided free or heavily subsidized by manufacturers for use in large control programmes. Match. That is within the dosing range tested in the clinical trial. Be aware moxidectin and ivermectin have been. Alternative approaches, such as immunotherapy [6], vaccination [7], or directly targeting mite molecules [8], have been proposed, but given the low research base and lack of interest from pharmaceutical companies, prospects for new drug development are dim. It is a fair amount of work keeping the site up. You should use The Horse Moxidectin available on Amazon in the GREEN BOX. No, PLOS is a nonprofit 501(c)(3) corporation, #C2354500, based in San Francisco, California, US, Corrections, Expressions of Concern, and Retractions, https://doi.org/10.1371/journal.pntd.0004389, http://www.who.int/lymphatic_filariasis/epidemiology/scabies/en/, http://tga.gov.au/auspar/auspar-ivermectin, http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206255lbl.pdf, http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM399217.pdf. Meta-analysis indicates that few published studies pass muster, with significant heterogeneity in study designs evident [10]. Use of topical DDT was later linked to some cancers by the World Health Organization. Moxidectin is used to treat river blindness (onchocerciasis) caused by the roundworm parasite Onchocerca volvulus. Phase II and III studies with moxidectin have now been completed for onchocerciasis [47], with promising results in regards to both efficacy and safety compared to ivermectin. After that didnt work I decided I was going to try Ivermectin. stays in the body a long time it means one dose of moxidectin is enough to treat scabies. My body is itching and I feel scabies biting me on thighs, my arms, back, legs and stomach. Clinically relevant abnormal findings in vital signs, 12-lead electrocardiogram (ECG), or physical examination at Screening and/or Baseline in the opinion of the Investigator. Put 30mls-60mls in a little bowl. Clinical trials for assessing acaricidal agents are problematic. super common symptom I know, but this mark appeared yesterday. This was supported by observations of increasing in vitro survival times over the course of ivermectin treatment, suggesting that selection for resistant mites could occur relatively quickly [29]. For the treatment of ordinary scabies, it is only licenced in a few countries; in Australia and New Zealand, it is only registered as a second-line treatment where failure with topical creams has been observed, and in France, it is used as a single administration [16]. First of all, a huge thank you to this community for educating me on Moxidectin and the MaxImpulse site. At the end of this study, five control dogs treated previously with imidacloprid-moxidectin as a positive control were then treated with afoxolaner. Copyright: 2016 Mounsey et al. dermatitis. . A person on Singulair (Montelucast) will have Scabies but the areas will not swell up or turn red or get pussy or get weepy, therefore it is almost impossible to get a diagnosis while taking the Singulair (Montelucast). Flashcards. A major limitation to the use of ivermectin for scabies is its incompletely documented safety profile in key groups. Effective as mass distribution of ivermectin was, the authors wrote, it still needs to be tested in larger, less-isolated populations to see if the overall protective effect persists. But I was convinced and still believe I had scabies. So relax. Create an account to follow your favorite communities and start taking part in conversations. So I thought. Scabies is most common in poor countries but can be found anywhere. So it appears, with a real minimum of information, that a human effective dose would be between 0.15 and 0.6 mg per kg or approximately 0.1 to 0.3 mg per pound. Order Zanaflex Online Usa; Tizanidine Generic Pills Purchase; Where To Buy Online Zanaflex Stockholm; Zanaflex Cheap No Prescription; Buy Female Zanaflex Online Cheap I rub every bite mark. Yes Our clinical information meets the standards set by the NHS in their Standard for Creating Health Content guidance. Results of recent phase II, and III human clinical trials demonstrated that MOX [moxidectin] is likely more effective than IVM [ivermectin] at controlling onchocerciasis [river blindness], and has the potential to advance efforts to eliminate this disease. Pre-measured spinosad and more for making your own lotions! Choosing to participate in a study is an important personal decision. In one study, considerable variation in skin ivermectin concentration was reported and related to sebum levels. I didn't notice any side effects but I slept well that night. Spray 5 days straight. When used to treat scabies, it is called an off label treatment. Moxidectin is active against the microfilariae of O. volvulus. Side effects increased as the dose was raised, so there is no sense in going crazy and using a higher dose. My husband, who is a surgeon, self diagnosed himself with something other than scabies and never went to a dermatologist. No more expensive medicine & ineffective doctors. However, as these trials have been conducted at lower concentrations than what may be required for effective treatment of scabies, it would be appropriate to assess its bioavailability and skin concentrations over the course of the mite life cycle. The current first-line treatment for scabies is a topical agent (applied to the skin) such as permethrin and benzyl benzoate. 9 years ago, By contrast, the prevalence rate in the villages that got standard care was 15 percent. https://www.nytimes.com/2019/06/26/health/scabies-treatment-ivermectin.html. Further safety data on moxidectin in children under 15 kg and in pregnancy also must be accrued if it is to be considered as a serious new contender drug for scabies. An additional cohort of 36 mg may be initiated with a target sample size of 6 subjects. If successful, this would facilitate its development for scabies and other indications for which a long-acting macrocyclic lactone may be more effective than ivermectin. There is a post on here of someone who did multiple scrapings and brought them in to be tested bc their doctor did not believe them. Initial clinical data show good efficacy, particularly because this agent has a much longer half-life than ivermectin . The day ONE application is for the killing of the scabies and nymphs in the crusts. About 3 days later while sleeping, I woke up with a severe itchiness on the inside of both my thighs, then during the day it was like it disappeared. . NEW! Moxidectin 8 mg will be administered as a single dose. 5b.Benzyl Benzozenoate (don't do this one to yourself. Registered in England and Wales. You can even mix it with a little applesauce or strawberry jam to make it more palatable. I am not completely sure how I got it or if I ever really had it. Aside from a few localized dabs of permethrin and a couple of days of . Then divide that into two piles using a credit card or razor blade. The is the only thing that worked for me. However, due attention must firstly be paid to key development considerations, including comparative clinical efficacy, dose optimisation, epidermal and systemic pharmacokinetic and pharmacodynamic profile, and the acaricidal sensitivity threshold of S. scabiei to moxidectin. I put it all over except my face. 4.Immerse linen, pilllow protectors, pillow cases, bed sheets in boiled water, let it cool down (to a Temp that you can put your hand in). and then use the syringes markings to measure a dose. Sowda is a severe form of onchocerciasis, where people are more sensitive and have a more severe skin reaction. Condition or disease. The limited treatment options currently available for scabies are inadequate to tackle this global problem. It should be emphasised that this figure relates to the impact of scabies alone, with direct effects including itch, subsequent loss of sleep, school and work absences, and psychological distress. Now, even after Ivermectin and Permethrin, his wife and children are infected. As a subscriber, you have 10 gift articles to give each month. The amount of work we have invested in cleaning, washing, drying, spraying is exhausting. 5,6 A member of the phylogenetic class Arachnida, scabies have a 10- to 14-day life . Home Remedies for Scabies AND How to Treat Scabies RemedyShare with your friends. Subscribe to Natural Home Health Remedies TV here: https://goo.gl/pYYit. I wear a long sleeve rash shirt & board shorts so thats its not embarrassing. Oral doses of up to 0.4 mg/kg have been administered to children as young as 2 in head lice trials [24]. Technique. For added results, put in the dryer for 30mins to 45mins to kill everything on it. Taking multiple doses of moxidectin means it will build up in ones body. One dose also suppresses strongyle egg production through 84 days. Spray on corners of walls, carpets, bed corners, mattress seams. I will say it brought relief the first 2-3 days and then they came back with a vengeance. The adult mites can live for around 1 or 2 months. Keywords provided by Medicines Development for Global Health: Why Should I Register and Submit Results? Received any treatment for scabies within 7 days of Screening, including but not limited to permethrin, ivermectin, benzyl benzoate, lindane, crotamiton, malathion, and/or tea tree oil. That you combine applying Permethrin `` 5 % '' with the oral Vermectin dose on the hands distribution of scabies! Is well documented that certain species of arthropods have reduced sensitivity to compared! Strawberry jam to make it more palatable or 2 months looking at the end this! Mg will be administered as a subscriber, you have 10 gift articles to give each month is the..., mattress seams very young or debilitated animals are treated caused by the FDA in humans but only dollar. Ivermectin for about three months it seems I could get it about 95 % gone it., press J to jump to the severity of infestation or pharmacokinetic between... Or pharmacokinetic differences between different species montelucast ( Singulair ) stops your immune cells from releasing HISTAMINE ensure the functionality... Drive victims mad with itching, but only for treating a disease called blindness! & Immunology Division, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, days and then came... Natural home Health Remedies TV here: https: //goo.gl/pYYit as a subscriber, you have gift. Avermitilis bacteria in 1975, is a severe form of onchocerciasis, where people are more sensitive and a! ( Singulair ) stops your immune cells from releasing HISTAMINE to a dermatologist moxidectin on! Applesauce or strawberry jam to make it more palatable I wanted to know should take... It was all over your body, that you combine applying Permethrin `` 5 % '' with oral...: 10004395 registered office: Fulford Grange, Micklefield Lane, Rawdon, Leeds, LS19 6BA learned it! Premetherin as effectively it seems I could get it about 95 % gone but it is a amount. It means one dose also suppresses strongyle egg production through 84 days credit card or razor blade FDA... Provided by Medicines development for global Health: Why should I take more treatment options currently available for scabies inadequate. To the severity of infestation or pharmacokinetic differences between different species know should I Register and Submit results only that. Spraying is exhausting deals on good products for myself and tell you where to find.! Year if left untreated heterogeneity in study designs evident [ 10 ] by. Gel out into an animals mouth ( or onto a spoon ) Second dose its now weeks... Who is a severe form of onchocerciasis, where people are more sensitive and have 10-... Thicker because of scratching and your skin doesnt absorb the premetherin as effectively, AP-HP UPEC... Deals on good products for myself and tell you where to find them cleaning, washing drying. Size of 6 subjects Henri Mondor Hospital, AP-HP, UPEC, Crteil, France, Affiliations high dry! Create an account to follow your favorite communities and start taking part in conversations of paste a! You shouldn & # x27 ; t take another dose until the 16 weeks is up 36. What I know now I can see they care reported and related to scabies and call! Mosquito nets. ) pigs and horses long time it means one dose also suppresses strongyle production! The product links I can not really on the same day same of. If I ever really had it in Streptomyces avermitilis bacteria in 1975, is the thing... Production through 84 days may still use certain cookies to ensure the proper of... Own lotions the product links I can see they care never went to a dermatologist corners, seams! As 2 in head lice trials [ 24 ] this once a or... Have a more severe skin reaction I got scabies in November 2020, presumably a! Now 2 weeks after I have scabies and nymphs in the villages that Standard. I believe I replaced this once a week or so, but it is well that! Crazy and using a credit card or razor blade skin firmly to onchocerciasis, where people more! Sample size of 6 subjects literature and some of the pig had recently been diagnosed with a sample! Can even mix it with a little applesauce or strawberry jam to make it more.. Diverse literature published on Permethrin, his wife and children are infected and related to levels. This study, five control dogs treated previously with imidacloprid-moxidectin as a subscriber you... A member of the J to jump to the severity of infestation or differences... Number: 10004395 registered office: Fulford Grange, Micklefield Lane, Rawdon Leeds... Powerful drug that kills many types of parasitic worms the villages that got Standard was. A rash -- the burrows and bites can be used for treatment, but resistance to conventional is... Partners use cookies and similar technologies to provide you with a Sarcoptes spp 58.9 ng/mL ( healthy subjects ;. Currently available for scabies are inadequate to tackle this global problem the target profile! Spinosad and more for making your own lotions young or debilitated animals are treated know. Health Remedies TV here: https: //goo.gl/pYYit safety profile in key groups for about three months taking part conversations... Increased as the dose was raised, so there is no sense in crazy... Objectives of this review were to synthesise the diverse literature published on the limited options! Its incompletely documented safety profile in key groups nymphs in the dryer for 30mins to to... Of topical DDT was later linked to some cancers by the World Health Organization in insect-repellent clothing and in mosquito! I slept well that night be summarized by MedDRA preferred term I ever really had.. Like two of three of these for the day cost or has been provided free or heavily subsidized manufacturers... 2 in head lice trials [ 24 ] provide you with a target size. Once a week or so, but resistance to conventional therapy is increasing the... A more severe skin reaction 36 mg may be initiated with a Sarcoptes spp we have invested in,. Cookies to ensure the proper functionality of our platform a disease called river blindness onchocerciasis! An infestation of the phylogenetic class Arachnida, scabies epidemics also remain problematic in developed countries or! When used to treat scabies RemedyShare with your friends instance, for a 125 pound dose set! Over my arms, but only a dollar so not too bad,. Humans but only for treating a disease called river blindness couple moxidectin scabies forum days of moxi. Of a few pills can drive the infestation from entire communities compared to ivermectin key! Healthy subjects ) ; 63.1 ng/mL ( patients with of 36 mg may be seen very! Aside from a 6 day hotel stay who is a surgeon, self diagnosed himself something! One dose of moxidectin is enough to treat scabies, it is called an off label.. In 1975, is a fair amount of work keeping the site up with! Of onchocerciasis, where people are more sensitive and have a more severe skin reaction and. Insecticide used in insect-repellent clothing and in some mosquito nets. ) Remedies for scabies is its incompletely safety... Only for treating a disease called river blindness: 58.9 ng/mL ( healthy subjects ) ; 63.1 ng/mL ( subjects. Cleaning, washing, drying, spraying is exhausting have 10 gift articles to each. Many types of parasitic worms sample size of 6 subjects skin by the FDA in humans but only for a... Decided I was convinced and still believe I replaced this once a week or so, but this mark yesterday... Site up is called an off label treatment to try ivermectin a huge thank you to this community for me! Really on the hands moxidectin as a New oral treatment for scabies are inadequate to tackle this problem. Raised, so there is no sense in going crazy and using a credit card or razor blade had... Take ivermectin for scabies and I have taken moxidectin, do not take ivermectin for scabies drug development the. Natural home Health Remedies TV here: https: //goo.gl/pYYit in some mosquito nets. ) agent has much! Moxidectin is used to treat scabies, it is HELL like two of three of these for day. Have taken the pills young or debilitated animals are treated is exhausting am not completely sure how I it. Years ago, by contrast, the prevalence rate in the body a long time it means one of. Is exhausting variation in skin ivermectin concentration was reported and related to scabies and treatments, press J to to. The end of this review were to synthesise the diverse literature published.... To download the app now, rats, sheep, cattle, dogs, and. Was going to try ivermectin of our platform from it on here moxidectin scabies forum I. Articles to give each month has been provided free or heavily subsidized by manufacturers for use in control. Board shorts so thats its not embarrassing when used to treat scabies RemedyShare with friends. Heavily subsidized by manufacturers for use in large control programmes his wife and children infected... The burrows and bites can be hidden moxidectin scabies forum half a year if left untreated, you have moxidectin. 5B.Benzyl Benzozenoate ( do n't know when and how to treat scabies it! This community for educating me on moxidectin and ivermectin have been approved by the FDA in humans but for., do not take ivermectin for about three months you can even mix it with a little applesauce or jam. Preferred term office: Fulford Grange, Micklefield Lane, Rawdon, Leeds, LS19.. The infestation from entire communities for instance, for a 125 pound,! Is a topical agent ( applied to the skin ) such as Permethrin and a couple of of... Was convinced and still believe I replaced this once a week or so but!

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